A 15-year-old girl comes to the physician because of a 3-month history of acne. Breast and pubic hair
development began at the age of 12 years. Menarche occurred at the age of 14 years. Physical
examination shows scattered open and closed comedones over the cheeks and forehead. Breast and
pubic hair development is Tanner stage 5. Which of the following is the most likely underlying cause of this
patient's acne?
A 67-year-old woman who has been in very good health is brought to her physician's office by her husband.
He states that over the course of the past 5 years she has had difficulty recognizing her grandchildren, she
has not been able to plan their daily activities, she has forgotten things left cooking on the stove, and at
night she has been wandering through the house with an “absent” look on her face. She is beginning to
demonstrate difficulty in recalling the names of common objects, and her speech is limited to simple two- or
three-word sentences. Which of the following is the most likely diagnosis?
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